WIPI2 Rabbit rabbit pAb

Applications: IHC;IF
Reactivity: Human;Mouse;Rat
Source: Rabbit
Dilution: IHC-p 1:50-300
Immunogen: Recombinant Protein of WIPI2
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed_band(KD): 49kD
Human_gene_id: 26100
Human_swiss_prot_no: Q9Y4P8
Subcellular_location: Preautophagosomal structure membrane ; Peripheral membrane protein ; Cytoplasmic side . Localizes to omegasomes membranes which are endoplasmic reticulum connected structures at the origin of preautophagosomal structures. Enriched at preautophagosomal structure membranes in response to PtdIns3P. .
Other_name: WD repeat domain phosphoinositide-interacting protein 2 (WIPI-2;WIPI49-like protein 2)
Background: WD repeat domain, phosphoinositide interacting 2(WIPI2) Homo sapiens WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).[supplied by OMIM, Mar 2008],