BMPR-II rabbit pAb

Applications: WB; ELISA
Reactivity: Human;Mouse;Rat;Monkey
Source: Rabbit
Dilution: WB 1:1000-2000 ELISA 1:5000-20000
Immunogen: Synthesized peptide derived from human BMPR-II
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Human_gene_id: 659
Human_swiss_prot_no: Q13873
Subcellular_location: Cell membrane ; Single-pass type I membrane protein.
Other_name: Bone morphogenetic protein receptor type-2 (BMP type-2 receptor;BMPR-2;EC 2.7.11.30;Bone morphogenetic protein receptor type II;BMP type II receptor;BMPR-II)
Background: This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disea