ITGA2B (light chain form 1, Cleaved-Gln891) rabbit pAb

Applications: WB;IHC
Reactivity: Human;Rat;Mouse;
Source: Rabbit
Dilution: WB 1:500-2000;IHC-p 1:50-300
Immunogen: Synthesized peptide derived from human ITGA2B (light chain form 1, Cleaved-Gln891)
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed_band(KD): 16 110kD
Human_gene_id: 3674
Human_swiss_prot_no: P08514
Subcellular_location: Membrane; Single-pass type I membrane protein.
Other_name: Integrin alpha-IIb (GPalpha IIb;GPIIb;Platelet membrane glycoprotein IIb;CD antigen CD41) [Cleaved into: Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain, form 1; Integrin alpha-IIb light chain, form 2]
Background: This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia. [provided by RefSeq, Jan 2016],