Collagen XVIII α1 (Cleaved-His1572) rabbit pAb

Applications: WB; ELISA
Reactivity: Human;Mouse
Source: Rabbit
Dilution: WB 1:1000-2000 ELISA 1:5000-20000
Immunogen: Synthesized peptide derived from human Collagen XVIII α1 (Cleaved-His1572)
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed_band(KD): 20 200kD
Human_gene_id: 80781
Human_swiss_prot_no: P39060
Subcellular_location: Secreted, extracellular space, extracellular matrix . Secreted, extracellular space, extracellular matrix, basement membrane .; [Non-collagenous domain 1]: Secreted, extracellular space, extracellular matrix, basement membrane . Secreted .; [Endostatin]: Secreted . Secreted, extracellular space, extracellular matrix, basement membrane .
Other_name: Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin]
Background: This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],