FA11 (heavy chain, Cleaved-Arg387) rabbit pAb

Applications: WB; ELISA
Reactivity: Human; Mouse
Source: Rabbit
Dilution: WB 1:1000-2000 ELISA 1:5000-20000
Immunogen: Synthesized peptide derived from human FA11 (heavy chain, Cleaved-Arg387)
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed_band(KD): 40 66kD
Human_gene_id: 2160
Human_swiss_prot_no: P03951
Subcellular_location: Secreted.
Other_name: Coagulation factor XI (FXI;EC 3.4.21.27;Plasma thromboplastin antecedent;PTA) [Cleaved into: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain]
Background: This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008],