Caspase 4 (p10, Cleaved-Ala290) rabbit pAb

Applications: WB; ELISA
Reactivity: Human
Source: Rabbit
Dilution: WB 1:1000-2000 ELISA 1:5000-20000
Immunogen: Synthesized peptide derived from human Caspase 4 (p10, Cleaved-Ala290)
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed_band(KD): 10 42kD
Human_gene_id: 837
Human_swiss_prot_no: P49662
Subcellular_location: Cytoplasm, cytosol . Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Mitochondrion . Inflammasome . Secreted . Predominantly localizes to the endoplasmic reticulum (ER). Association with the ER membrane requires TMEM214 (PubMed:15123740). Released in the extracellular milieu by keratinocytes following UVB irradiation (PubMed:22246630). .
Other_name: Caspase-4 (CASP-4;EC 3.4.22.57;ICE(rel)-II;Protease ICH-2;Protease TX) [Cleaved into: Caspase-4 subunit 1; Caspase-4 subunit 2]
Background: catalytic activity:Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|- but also cleaves at Asp-Glu-Val-Asp-|-.,function:Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1.,PTM:The two subunits are derived from the precursor sequence by an autocatalytic mechanism or by cleavage by Caspase-8.,similarity:Belongs to the peptidase C14A family.,similarity:Contains 1 CARD domain.,subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a small and a large subunit.,tissue specificity:Widely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain.,