CARD11 (phospho-Ser652) rabbit pAb

Applications: WB
Reactivity: Human;Mouse;Rat
Source: Rabbit
Dilution: WB 1:1000-2000
Immunogen: Synthesized phosho peptide around human CARD11 (Ser652)
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed_band(KD): 130kD
Human_gene_id: 84433
Human_swiss_prot_no: Q9BXL7
Subcellular_location: Cytoplasm . Membrane raft . Colocalized with DPP4 in membrane rafts. .
Other_name: Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 1) (Carma 1)
Background: The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008],