Caspase 10 (p23/17, Cleaved-Val220) Rabbit pAb

Applications: WB; ELISA
Reactivity: Human; Mouse; Rat
Source: Rabbit
Dilution: WB 1:500-2000, ELISA(peptide)1:5000-20000
Immunogen: Synthesized peptide derived from human Caspase 10 (p23/17, Cleaved-Val220)
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed_band(KD): 58+23kD
Human_gene_id: 843
Human_swiss_prot_no: Q92851
Subcellular_location: cytosol,CD95 death-inducing signaling complex,ripoptosome,
Other_name: Caspase-10 (CASP-10;EC 3.4.22.63;Apoptotic protease Mch-4;FAS-associated death domain protein interleukin-1B-converting enzyme 2;FLICE2;ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12]
Background: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011],