CENP-M rabbit pAb

Applications: IHC;IF;WB
Reactivity: Human;Rat;Mouse;
Source: Rabbit
Dilution: IHC-p 1:50-200, WB 1:500-2000
Immunogen: Synthesized peptide derived from human CENP-M AA range: 30-110
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed_band(KD): 20kD
Human_gene_id: 79019
Human_swiss_prot_no: Q9NSP4
Subcellular_location: Nucleus. Cytoplasm. Chromosome, centromere, kinetochore. Nuclear in non-confluent cells and cytoplasmic in confluent or dividing cells (By similarity). Localizes in the kinetochore domain of centromeres. .
Other_name: Centromere protein M (CENP-M;Interphase centromere complex protein 39;Proliferation-associated nuclear element protein 1)
Background: The protein encoded by this gene is an inner protein of the kinetochore, the multi-protein complex that binds spindle microtubules to regulate chromosome segregation during cell division. It belongs to the constitutive centromere-associated network protein group, whose members interact with outer kinetochore proteins and help to maintain centromere identity at each cell division cycle. The protein is structurally related to GTPases but cannot bind guanosine triphosphate. A point mutation that affects interaction with another constitutive centromere-associated network protein, CENP-I, impairs kinetochore assembly and chromosome alignment, suggesting that it is required for kinetochore formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015],