DNAJC2/MPP11 (phospho-Ser47) rabbit pAb

Applications: WB
Reactivity: Human;Mouse;Rat
Source: Rabbit
Dilution: WB 1:1000-2000
Immunogen: Synthesized phosho peptide around human DNAJC2 and MPP11 (Ser47)
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed_band(KD): 68kD
Human_gene_id: 27000
Human_swiss_prot_no: Q99543
Subcellular_location: Nucleus . Cytoplasm, cytosol .
Other_name: DnaJ homolog subfamily C member 2 (M-phase phosphoprotein 11) (Zuotin-related factor 1)
Background: This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described. [provided by RefSeq, Jul 2008],