eNOS (Phospho-Ser1179) rabbit pAb

Applications: IHC;IF;WB
Reactivity: Human; Mouse; Rat
Source: Rabbit
Dilution: IHC-p 1:50-200, WB 1:500-2000
Immunogen: Synthesized peptide derived from human eNOS (Phospho-Ser1179)
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed_band(KD): 130-140kD
Human_gene_id: 4846
Human_swiss_prot_no: P29474
Subcellular_location: Cell membrane. Membrane, caveola. Cytoplasm, cytoskeleton. Golgi apparatus. Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity.
Other_name: Nitric oxide synthase, endothelial (EC 1.14.13.39;Constitutive NOS;cNOS;EC-NOS;Endothelial NOS;eNOS;NOS type III;NOSIII)
Background: Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009],