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ELK Biotechnology
SKU:ES16551
FACR1 rabbit pAb
FACR1 rabbit pAb
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$250.00 USD
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Applications: WB
Reactivity: Human; Mouse;Rat
Source: Rabbit
Dilution: WB 1：500-2000
Immunogen: Synthesized peptide derived from human FACR1 AA range: 135-185
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Human_gene_id: 84188
Human_swiss_prot_no: Q8WVX9
Subcellular_location: Peroxisome membrane ; Single-pass membrane protein .
Background: The protein encoded by this gene is required for the reduction of fatty acids to fatty alcohols, a process that is required for the synthesis of monoesters and ether lipids. NADPH is required as a cofactor in this reaction, and 16-18 carbon saturated and unsaturated fatty acids are the preferred substrate. This is a peroxisomal membrane protein, and studies suggest that the N-terminus contains a large catalytic domain located on the outside of the peroxisome, while the C-terminus is exposed to the matrix of the peroxisome. Studies indicate that the regulation of this protein is dependent on plasmalogen levels. Mutations in this gene have been associated with individuals affected by severe intellectual disability, early-onset epilepsy, microcephaly, congenital cataracts, growth retardation, and spasticity (PMID: 25439727). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jan 2015],
Reactivity: Human; Mouse;Rat
Source: Rabbit
Dilution: WB 1：500-2000
Immunogen: Synthesized peptide derived from human FACR1 AA range: 135-185
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Human_gene_id: 84188
Human_swiss_prot_no: Q8WVX9
Subcellular_location: Peroxisome membrane ; Single-pass membrane protein .
Background: The protein encoded by this gene is required for the reduction of fatty acids to fatty alcohols, a process that is required for the synthesis of monoesters and ether lipids. NADPH is required as a cofactor in this reaction, and 16-18 carbon saturated and unsaturated fatty acids are the preferred substrate. This is a peroxisomal membrane protein, and studies suggest that the N-terminus contains a large catalytic domain located on the outside of the peroxisome, while the C-terminus is exposed to the matrix of the peroxisome. Studies indicate that the regulation of this protein is dependent on plasmalogen levels. Mutations in this gene have been associated with individuals affected by severe intellectual disability, early-onset epilepsy, microcephaly, congenital cataracts, growth retardation, and spasticity (PMID: 25439727). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jan 2015],
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