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ELK Biotechnology
SKU:ES16461
FILA2 rabbit pAb
FILA2 rabbit pAb
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$250.00 USD
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Applications: WB
Reactivity: Human; Mouse
Source: Rabbit
Dilution: WB 1：500-2000
Immunogen: Synthesized peptide derived from human FILA2 AA range: 402-452
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Human_gene_id: 388698
Human_swiss_prot_no: Q5D862
Subcellular_location: Cytoplasm . Cytoplasmic granule . In the stratum corneum of the epidermis, dispersed diffusely throughout the cytoplasm, while in the stratum granulosum, localized within keratohyalin granules (PubMed:19384417) (PubMed:21531719). In granular keratinocytes and in lower corneocytes, colocalizes with calpain-1/CAPN1. .
Background: The filaggrin-like protein encoded by this gene is upregulated by calcium, proteolyzed by calpain 1, and is involved in epithelial homeostasis. The encoded protein is required for proper cornification in skin, with defects in this gene being associated with skin diseases. This protein also has a function in skin barrier protection. In fact, in addition to providing a physical barrier, C-terminal fragments of this protein display antimicrobial activity against P. aeruginosa. [provided by RefSeq, Dec 2015],
Reactivity: Human; Mouse
Source: Rabbit
Dilution: WB 1：500-2000
Immunogen: Synthesized peptide derived from human FILA2 AA range: 402-452
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Human_gene_id: 388698
Human_swiss_prot_no: Q5D862
Subcellular_location: Cytoplasm . Cytoplasmic granule . In the stratum corneum of the epidermis, dispersed diffusely throughout the cytoplasm, while in the stratum granulosum, localized within keratohyalin granules (PubMed:19384417) (PubMed:21531719). In granular keratinocytes and in lower corneocytes, colocalizes with calpain-1/CAPN1. .
Background: The filaggrin-like protein encoded by this gene is upregulated by calcium, proteolyzed by calpain 1, and is involved in epithelial homeostasis. The encoded protein is required for proper cornification in skin, with defects in this gene being associated with skin diseases. This protein also has a function in skin barrier protection. In fact, in addition to providing a physical barrier, C-terminal fragments of this protein display antimicrobial activity against P. aeruginosa. [provided by RefSeq, Dec 2015],
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