NEUG rabbit pAb

Applications: IHC;IF
Reactivity: Human; Mouse;Rat
Source: Rabbit
Dilution: IHC-p 1：50-200
Immunogen: Synthesized peptide derived from human NEUG AA range: 23-73
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Human_gene_id: 4900
Human_swiss_prot_no: Q92686
Subcellular_location: nucleus,trans-rk transport vesicle membrane,postsynaptic density,axon,mitochondrial membrane,neuronal cell body,dendritic spine head,
Background: Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects. [provided by RefSeq, Jul 2008],