Nuclear Receptor NR4A1 (Phospho-Ser351) Rabbit pAb

Applications: WB; ELISA
Reactivity: Human; Mouse; Rat
Source: Rabbit
Dilution: WB 1:500-2000, ELISA(peptide)1:5000-20000
Immunogen: Synthesized pospho peptide derived from human Nuclear Receptor NR4A1 (Phospho-Ser351)
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed_band(KD): 77kD
Human_gene_id: 3164
Human_swiss_prot_no: P22736
Subcellular_location: Nucleus . Cytoplasm . Mitochondrion . Nuclear export to the cytoplasm is XPO1-mediated and positively regulated by IFI27 (PubMed:22427340). Translocation to the mitochondrion upon interaction with RXRA and upon the presence of 9-cis retinoic acid (PubMed:17761950). .
Other_name: Nuclear receptor subfamily 4 group A member 1 (Early response protein NAK1;Nuclear hormone receptor NUR/77;Nur77;Orphan nuclear receptor HMR;Orphan nuclear receptor TR3;ST-59;Testicular receptor 3)
Background: This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011],