PLCD3 rabbit pAb

Applications: WB;IHC
Reactivity: Human; Mouse
Source: Rabbit
Dilution: WB 1:500-2000;IHC-p 1:50-300
Immunogen: Synthesized peptide derived from human PLCD3 AA range: 501-551
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Human_gene_id: 113026
Human_swiss_prot_no: Q8N3E9
Subcellular_location: Membrane; Peripheral membrane protein. Cytoplasm. Cleavage furrow . Localizes at the cleavage furrow during cytokinesis. .
Background: This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids. [provided by RefSeq, Jul 2008],