S26A5 rabbit pAb

Applications: WB;IHC;IF;ELISA
Reactivity: Human; Mouse; Rat
Source: Rabbit
Dilution: IHC-p 1:100-500
Immunogen: Synthesized peptide derived from human S26A5
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed_band(KD): 81kD
Human_gene_id: 375611
Human_swiss_prot_no: P58743
Subcellular_location: Cell membrane ; Multi-pass membrane protein . Lateral wall of outer hair cells. .
Other_name: Prestin (Solute carrier family 26 member 5)
Background: This gene encodes a member of the SLC26A/SulP transporter family. The protein functions as a molecular motor in motile outer hair cells (OHCs) of the cochlea, inducing changes in cell length that act to amplify sound levels. The transmembrane protein is an incomplete anion transporter, and does not allow anions to cross the cell membrane but instead undergoes a conformational change in response to changes in intracellular Cl- levels that results in a change in cell length. The protein functions at microsecond rates, which is several orders of magnitude faster than conventional molecular motor proteins. Mutations in this gene are potential candidates for causing neurosensory deafness. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009],