SPTN4 rabbit pAb

Applications: IHC;IF
Reactivity: Human;Rat;Mouse;
Source: Rabbit
Dilution: IHC-p 1:50-300
Immunogen: Synthesized peptide derived from part region of human protein
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed_band(KD): 282kD
Human_gene_id: 57731
Human_swiss_prot_no: Q9H254
Subcellular_location: Cytoplasm, cytoskeleton . Cytoplasm, cell cortex .
Background: Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein localizes to the nuclear matrix, PML nuclear bodies, and cytoplasmic vesicles. A highly similar gene in the mouse is required for localization of specific membrane proteins in polarized regions of neurons. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],