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ELK Biotechnology
SKU:ES10279
SCN1B rabbit pAb
SCN1B rabbit pAb
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$250.00 USD
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Applications: WB;ELISA
Reactivity: Human;Rat;Mouse
Source: Rabbit
Dilution: WB 1:500-2000 ELISA 1:5000-20000
Immunogen: Synthesized peptide derived from part region of human protein
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed_band(KD): 23kD
Human_gene_id: 6324
Human_swiss_prot_no: Q07699
Subcellular_location: [Isoform 1]: Cell membrane ; Single-pass type I membrane protein . Perikaryon . Cell projection . Cell projection, axon . Detected at nodes of Ranvier on the sciatic nerve. .; [Isoform 2]: Perikaryon . Cell projection . Secreted . Detected on Purkinje cells and their cell projections and on neuronal cell projections. .
Background: Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009],
Reactivity: Human;Rat;Mouse
Source: Rabbit
Dilution: WB 1:500-2000 ELISA 1:5000-20000
Immunogen: Synthesized peptide derived from part region of human protein
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed_band(KD): 23kD
Human_gene_id: 6324
Human_swiss_prot_no: Q07699
Subcellular_location: [Isoform 1]: Cell membrane ; Single-pass type I membrane protein . Perikaryon . Cell projection . Cell projection, axon . Detected at nodes of Ranvier on the sciatic nerve. .; [Isoform 2]: Perikaryon . Cell projection . Secreted . Detected on Purkinje cells and their cell projections and on neuronal cell projections. .
Background: Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009],
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