AT2B2 rabbit pAb

Applications: WB;ELISA
Reactivity: Human;Rat
Source: Rabbit
Dilution: WB 1:500-2000 ELISA 1:5000-20000
Immunogen: Synthesized peptide derived from human protein . at AA range: 250-330
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed_band(KD): 136kD
Human_gene_id: 491
Human_swiss_prot_no: Q01814
Subcellular_location: Cell membrane ; Multi-pass membrane protein . Cell junction, synapse .; [Isoform WA]: Apical cell membrane ; Multi-pass membrane protein . Basolateral cell membrane ; Multi-pass membrane protein .; [Isoform WB]: Apical cell membrane ; Multi-pass membrane protein . Basolateral cell membrane ; Multi-pass membrane protein .; [Isoform XB]: Basolateral cell membrane ; Multi-pass membrane protein .; [Isoform ZA]: Basolateral cell membrane ; Multi-pass membrane protein .; [Isoform ZB]: Basolateral cell membrane ; Multi-pass membrane protein .
Background: The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 2. Alternatively spliced tran