ERO1A Antibody

Size

100ul

Clone Number

Aliases

Endoplasmic oxidoreductin 1 like protein antibody; Endoplasmic oxidoreductin-1-like protein antibody; Endoplasmic reticulum oxidoreductase 1 alpha antibody; Endoplasmic reticulum oxidoreductin 1-like antibody; ERO1 alpha antibody; ERO1 L antibody; ERO1 Lalpha antibody; ERO1 like protein alpha antibody; ERO1-alpha antibody; ERO1-L antibody; ERO1-L-alpha antibody; ERO1-like (S. cerevisiae) antibody; ERO1-like alpha antibody; ERO1-like protein alpha antibody; ERO1-like; S. cerevisiae; homolog of; alpha antibody; ERO1A antibody; ERO1A_HUMAN antibody; ERO1L antibody; ERO1LA antibody; Oxidoreductin 1 Lalpha antibody; Oxidoreductin-1-L-alpha antibody; PRO865 antibody; UNQ434 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q96HE7

Immunogen

Recombinant Human ERO1-like protein alpha protein (24-260AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

Background

Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

ERO1A

Research Areas

Signal transduction