ERI1 Antibody

Size

100ug

Clone Number

Aliases

3' 5' exonuclease ERI 1 antibody; 3' 5' exonuclease ERI1 antibody; 3' EXO antibody; 3' exoribonuclease antibody; 3' HEXO antibody; 3' histone mRNA exonuclease 1 antibody; 3''-5'' exonuclease eri1 antibody; 3''-5'' exoribonuclease 1 antibody; 3'EXO antibody; 3'HEXO antibody; ERI 1 antibody; Eri 1 homolog antibody; Eri-1 homolog antibody; eri1 antibody; Eri1 homolog antibody; ERI1_HUMAN antibody; HEXO antibody; Histone mRNA 3' end specific exonuclease antibody; Histone mRNA 3' end specific exoribonuclease antibody; Histone mRNA 3''-end-specific exoribonuclease antibody; Histone mRNA 3''-exonuclease 1 antibody; MGC35395 antibody; Protein 3''hExo antibody; THEX 1 antibody; THEX1 antibody; Three prime histone mRNA exonuclease 1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q8IV48

Immunogen

Recombinant Human 3\\\'-5\\\' exoribonuclease 1 protein (2-66AA)

Raised in

Rabbit

Species Reactivity

Human, Rat

Tested Applications

ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500, IF:1:50-1:200

Background

RNA exonuclease that binds to the 3\\\'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2\\\' and 3\\\'-hydroxyl groups at the last nucleotide of the histone 3\\\'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3\\\'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5\\\'-ACCCA-3\\\' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3\\\'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

ERI1

Research Areas

Epigenetics and Nuclear Signaling