EPRS Antibody

Size

100ug

Clone Number

Aliases

Bifunctional aminoacyl tRNA synthetase antibody; Bifunctional aminoacyl-tRNA synthetase antibody; Bifunctional glutamate/proline tRNA ligase antibody; Cell proliferation-inducing gene 32 protein antibody; DKFZp313B047 antibody; EARS antibody; Eprs antibody; GLNS antibody; Glu pro tRNA synthetase antibody; GLUPRORS antibody; GluRS antibody; Glutamate tRNA ligase antibody; Glutamatyl prolyl tRNA synthetase antibody; Glutaminyl tRNA synthetase antibody; Glutamyl prolyl tRNA synthetase antibody; Glutamyl tRNA synthetase antibody; Glutamyl-tRNA synthetase antibody; PARS antibody; PIG 32 antibody; PIG32 antibody; Proliferation inducing gene 32 protein antibody; Proliferation inducing protein 32 antibody; Proline tRNA ligase antibody; Proline--tRNA ligase antibody; Prolyl tRNA synthetase antibody; Prolyl-tRNA synthetase antibody; QARS antibody; QPRS antibody; SYEP_HUMAN antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P07814

Immunogen

Recombinant Human Bifunctional glutamate/proline--tRNA ligase protein (1207-1399AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000, IF:1:50-1:200

Background

Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the multisynthetase complex and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3\\\'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

EPRS

Research Areas

Epigenetics and Nuclear Signaling