EpoR(Phospho Tyr426) Polyclonal Antibody

Ab type

Primary antibody

Background

This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized phospho-peptide around the phosphorylation site of human EpoR (phospho Tyr426)

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

55065

synonyms

Erythropoietin receptor; EPOR; Erythropoietin receptor; EPO-R