EPHB2 Antibody, Biotin conjugated

Size

100ug

Clone Number

Aliases

cek5 antibody; Developmentally regulated EPH related tyrosine kinase antibody; DRT antibody; EK5 antibody; ELK related protein tyrosine kinase antibody; Eph receptor B2 antibody; EPH tyrosine kinase 3 antibody; EPH-like kinase 5 antibody; EPHB2 antibody; EPHB2_HUMAN antibody; Ephrin type B receptor 2 antibody; Ephrin type-B receptor 2 antibody; EPHT 3 antibody; ERK antibody; ETECK antibody; hEK5 antibody; Nuk antibody; Prkm 5 antibody; Receptor protein tyrosine kinase HEK 5 antibody; Renal carcinoma antigen NY-REN-47 antibody; Sek 3 antibody; Tyro 5 antibody; Tyrosine protein kinase receptor CEK 5 antibody; Tyrosine protein kinase receptor EPH 3 antibody; Tyrosine protein kinase receptor QEK 5 antibody; Tyrosine-protein kinase receptor EPH-3 antibody; Tyrosine-protein kinase TYRO5 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P29323

Immunogen

Recombinant Human Ephrin type-B receptor 2 protein (261-465AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Biotin

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

EPHB2

Research Areas

Neuroscience; Cancer; Cardiovascular; Signal transduction