EPHA8 Antibody

Size

100ul

Clone Number

Aliases

EPHA8 antibody; EEK antibody; HEK3 antibody; KIAA1459Ephrin type-A receptor 8 antibody; EC 2.7.10.1 antibody; EPH- and ELK-related kinase antibody; EPH-like kinase 3 antibody; EK3 antibody; hEK3 antibody; Tyrosine-protein kinase receptor EEK antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P29322

Immunogen

Recombinant Human Ephrin type-A receptor 8 protein (45-249AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IF; Recommended dilution: IF:1:50-1:200

Background

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity).

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

EPHA8

Research Areas

Others