EPHA4 Antibody, FITC conjugated

Size

100ug

Clone Number

Aliases

Cek 8 antibody; CEK8 antibody; EK8 antibody; eph receptor a4 antibody; EPH-like kinase 8 antibody; EPHA4 antibody; EPHA4_HUMAN antibody; Ephrin type-A receptor 4 antibody; HEK 8 antibody; hEK8 antibody; Receptor protein-tyrosine kinase HEK8 antibody; Sek 1 antibody; SEK antibody; TYRO 1 protein tyrosine kinase antibody; TYRO1 antibody; Tyrosine-protein kinase receptor SEK antibody; Tyrosine-protein kinase TYRO1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P54764

Immunogen

Recombinant Human Ephrin type-A receptor 4 protein (345-545AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

Background

Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at \'Tyr-15\' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

FITC

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

EPHA4

Research Areas

Neuroscience; Cardiovascular; Signal transduction