EPAS1 Antibody

Size

100ug

Clone Number

Aliases

Basic helix loop helix PAS protein MOP2 antibody; Basic-helix-loop-helix-PAS protein MOP2 antibody; bHLHe73 antibody; Class E basic helix-loop-helix protein 73 antibody; ECYT4 antibody; Endothelial PAS domain containing protein 1 antibody; Endothelial pas domain protein 1 antibody; Endothelial PAS domain-containing protein 1 antibody; EPAS 1 antibody; EPAS-1 antibody; EPAS1 antibody; EPAS1_HUMAN antibody; HIF 1 alpha like factor antibody; HIF 2 alpha antibody; HIF-1-alpha-like factor antibody; HIF-2-alpha antibody; HIF2-alpha antibody; HIF2A antibody; HLF antibody; Hypoxia inducible factor 2 alpha antibody; Hypoxia inducible factor 2 alpha subunit antibody; Hypoxia-inducible factor 2-alpha antibody; Member of PAS protein 2 antibody; Member of pas superfamily 2 antibody; MOP 2 antibody; MOP2 antibody; PAS domain-containing protein 2 antibody; PASD2 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q99814

Immunogen

Recombinant Human Endothelial PAS domain-containing protein 1 protein (543-870AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5\'-[AG]CGTG-3\' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

EPAS1

Research Areas

Epigenetics and Nuclear Signaling; Cancer; Cardiovascular; Metabolism