ENTPD5 Antibody

Size

100ul

Clone Number

Aliases

CD39 like 4 antibody; AI196558 antibody; AI987697 antibody; CD39 antigen like 4 antibody; CD39 antigen-like 4 antibody; CD39 like 4 antibody; CD39L4 antibody; Ectonucleoside triphosphate diphosphohydrolase 5 antibody; ENTP5_HUMAN antibody; Entpd5 antibody; ER UDPase antibody; ER-UDPase antibody; GDPase ENTPD5 antibody; Guanosine-diphosphatase ENTPD5 antibody; MGC163357 antibody; MGC163359 antibody; mNTPase antibody; NTPDase 5 antibody; Nucleoside diphosphatase antibody; PCPH antibody; Pcph proto oncogene protein antibody; Proto oncogene CPH antibody; UDPase ENTPD5 antibody; Uridine-diphosphatase ENTPD5 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O75356

Immunogen

Recombinant Human Ectonucleoside triphosphate diphosphohydrolase 5 protein (149-428AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse

Tested Applications

ELISA, WB, IHC, IP; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IP:1:200-1:2000

Background

Uridine diphosphatase (UDPase) that promotes protein N-glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

ENTPD5

Research Areas

Epigenetics and Nuclear Signaling; Cancer; Metabolism; Signal transduction