ENPP2 Antibody

Size

100ul

Clone Number

Aliases

ATX antibody; ATX X antibody; Autotaxin antibody; Autotaxin t antibody; E NPP 2 antibody; E-NPP 2 antibody; Ectonucleotide pyrophosphatase/phosphodiesterase 2 antibody; Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 antibody; Enpp2 antibody; ENPP2_HUMAN antibody; Extracellular lysophospholipase D antibody; FLJ26803 antibody; LysoPLD antibody; NPP2 antibody; PD IALPHA antibody; PDNP2 antibody; Phosphodiesterase I alpha antibody; Phosphodiesterase I/nucleotide pyrophosphatase 2 antibody; Plasma lysophospholipase D antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q13822

Immunogen

Recombinant Human Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 protein (564-863AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

ENPP2

Research Areas

Neuroscience; Cancer; Cardiovascular; Metabolism; Signal transduction