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ELK Biotechnology
SKU:EM1377
Acetyl NF kB P65（K314/K315) (5G11) Mouse mAb
Acetyl NF kB P65（K314/K315) (5G11) Mouse mAb
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$250.00 USD
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Applications: IHC
Reactivity: Human, Mouse, Rat
Source: Mouse
Dilution: IHC 1:100-200
Immunogen: Synthetic Peptide
Storage_stability: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Clonality: Monoclonal
Isotype: IgG1
Concentration: 1mg/mL
Observed_band(KD): 65kDa
Human_gene_id: 5970
Human_swiss_prot_no: Q04206
Subcellular_location: Cytoplasm, Nucleus
Other_name: NF kappa B p65, NFKB3, p65, p65 NF kB, RELA, TF65, Transcription Factor p65
Background: NFkB p65 is ubiquitinated leading to its proteosomal degradation, which is required for termination of the NFkB response. Phosphorylation of NFkB p65 on S536 stimulates acetylation of K310 by CBP, enhancing transcriptional activity. NFkB p65 is also acetylated at K122, enhancing DNA binding and impairing the interaction with NFKBIA. The protein is deacetylated by HDAC3. Invasion of a host by a pathogen is frequently associated with the activation of NF-kB, which coordinates various aspects of immune function required for resistance to infection.
Reactivity: Human, Mouse, Rat
Source: Mouse
Dilution: IHC 1:100-200
Immunogen: Synthetic Peptide
Storage_stability: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Clonality: Monoclonal
Isotype: IgG1
Concentration: 1mg/mL
Observed_band(KD): 65kDa
Human_gene_id: 5970
Human_swiss_prot_no: Q04206
Subcellular_location: Cytoplasm, Nucleus
Other_name: NF kappa B p65, NFKB3, p65, p65 NF kB, RELA, TF65, Transcription Factor p65
Background: NFkB p65 is ubiquitinated leading to its proteosomal degradation, which is required for termination of the NFkB response. Phosphorylation of NFkB p65 on S536 stimulates acetylation of K310 by CBP, enhancing transcriptional activity. NFkB p65 is also acetylated at K122, enhancing DNA binding and impairing the interaction with NFKBIA. The protein is deacetylated by HDAC3. Invasion of a host by a pathogen is frequently associated with the activation of NF-kB, which coordinates various aspects of immune function required for resistance to infection.
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