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ELK Biotechnology
SKU:EM1275
Cystatin C (7F11) Mouse mAb
Cystatin C (7F11) Mouse mAb
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$250.00 USD
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Applications: WB, IHC, ELISA
Reactivity: Human
Source: Mouse
Dilution: WB 1:1,000-2,000 IHC 1:100-200 ELISA 1:10,000-20,000
Immunogen: Recombinant Protein
Storage_stability: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Clonality: Monoclonal
Isotype: IgG1
Concentration: 1mg/mL
Observed_band(KD): 14kDa
Human_gene_id: 1471
Human_swiss_prot_no: P01034
Subcellular_location: Secreted
Other_name: AD8, Cystatin3, Gamma trace, HCCAA
Background: Cystatin C is a 13-kDa inhibitor of cysteine proteinases which is secreted by all cell types and is completely cleared from the organism through glomerular filtration, shown to be an early and sensitive biomarker of renal dysfunction. A mutation in Cystatin C has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. In addition, this protein has been shown to have an antimicrobial function, inhibiting the replication of herpes simplex virus.
Reactivity: Human
Source: Mouse
Dilution: WB 1:1,000-2,000 IHC 1:100-200 ELISA 1:10,000-20,000
Immunogen: Recombinant Protein
Storage_stability: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Clonality: Monoclonal
Isotype: IgG1
Concentration: 1mg/mL
Observed_band(KD): 14kDa
Human_gene_id: 1471
Human_swiss_prot_no: P01034
Subcellular_location: Secreted
Other_name: AD8, Cystatin3, Gamma trace, HCCAA
Background: Cystatin C is a 13-kDa inhibitor of cysteine proteinases which is secreted by all cell types and is completely cleared from the organism through glomerular filtration, shown to be an early and sensitive biomarker of renal dysfunction. A mutation in Cystatin C has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. In addition, this protein has been shown to have an antimicrobial function, inhibiting the replication of herpes simplex virus.
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