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ELK Biotechnology

SKU:EM1156

FH/Fumarase Mouse mAb

FH/Fumarase Mouse mAb

Regular price $250.00 USD
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Size
Applications: WB, IF
Reactivity: Human, Rat, Mouse
Source: Mouse
Dilution: WB 1:1,000-3,000 IF 1:100-200
Immunogen: Recombinant Protein
Storage_stability: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Clonality: Monoclonal
Isotype: IgG1
Concentration: 1mg/mL
Observed_band(KD): 50kDa
Human_gene_id: 2271
Human_swiss_prot_no: P07954
Subcellular_location: Cytoplasm, Mitochondrion
Other_name: Fumarase, fumarate hydratase, HLRCC, LRCC, MCL, MCUL1
Background: Fumarase (FH) is an enzyme that catalyzes the reversible hydration/dehydration of fumarate to malate. Fumarase comes in two forms: mitochondrial and cytosolic. The mitochondrial isoenzyme is involved in the Krebs Cycle (also known as the Tricarboxylic Acid Cycle [TCA] or the Citric Acid Cycle), and the cytosolic isoenzyme is involved in the metabolism of amino acids and fumarate. Subcellular localization is established by the presence of a signal sequence on the amino terminus in the mitochondrial form, while subcellular localization in the cytosolic form is established by the absence of the signal sequence found in the mitochondrial variety.
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