ELOB Antibody

Size

100ul

Clone Number

Aliases

EloB antibody; ELOB_HUMAN antibody; Elongin 18 kDa subunit antibody; Elongin B antibody; Elongin-B antibody; RNA polymerase II transcription factor SIII p18 subunit antibody; RNA polymerase II transcription factor SIII subunit B antibody; SIII antibody; SIII p18 antibody; TCEB 2 antibody; Tceb2 antibody; Transcription elongation factor B (SIII) polypeptide 2 antibody; Transcription elongation factor B polypeptide 2 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q15370

Immunogen

Recombinant Human Elongin-B protein (1-118AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200

Background

SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

ELOB

Research Areas

Epigenetics and Nuclear Signaling