eIF4G(Phospho-Ser1108) Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome| which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein| which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants| some of which are derived from alternative promoter usage.

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized phosho peptide around human eIF4G (Ser1108)

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

synonyms

eIF4G ;Ser1108; Eukaryotic translation initiation factor 4 gamma 1; eIF-4-gamma 1; eIF-4G 1; eIF-4G1; p220