EIF3A Antibody

Size

100ug

Clone Number

Aliases

centrosomin homolog antibody; cytoplasmic protein p167 antibody; eIF 3 theta antibody; eIF-3-theta antibody; EIF3 antibody; eIF3 p167 antibody; eIF3 p170 antibody; eIF3 p180 antibody; EIF3 p180 subunit antibody; eIF3 p185 antibody; eIF3 theta antibody; eIF3a antibody; EIF3A_HUMAN antibody; EIF3S10 antibody; eukaryotic translation initiation factor 3 subunit 10 (theta 150 170kD) antibody; eukaryotic translation initiation factor 3 subunit 10 (theta 170kD) antibody; eukaryotic translation initiation factor 3 subunit 10 170kDa antibody; Eukaryotic translation initiation factor 3 subunit 10 antibody; eukaryotic translation initiation factor 3 subunit 10 theta 150 170kDa antibody; Eukaryotic translation initiation factor 3 subunit A antibody; OTTHUMP00000020589 antibody; P167 antibody; p180 antibody; p185 antibody; TIF32 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q14152

Immunogen

Recombinant Human Eukaryotic translation initiation factor 3 subunit A protein (1288-1379AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IF; Recommended dilution: WB:1:500-1:5000, IF:1:50-1:200

Background

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation (PubMed:23766293, PubMed:24357634). In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

EIF3A

Research Areas

Others