EIF2S3 Antibody

Size

100ul

Clone Number

Aliases

eIF-2-gamma X antibody; eIF-2gA antibody; eIF-2gX antibody; EIF2 antibody; EIF2G antibody; EIF2gamma antibody; EIF2S3 antibody; Eukaryotic translation initiation factor 2 gamma antibody; Eukaryotic translation initiation factor 2 gamma subunit antibody; Eukaryotic translation initiation factor 2 subunit 3 antibody; Eukaryotic translation initiation factor 2 subunit 3 gamma 52kDa antibody; Eukaryotic translation initiation factor 2 subunit gamma X antibody; IF2G_HUMAN antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P41091

Immunogen

Recombinant Human Eukaryotic translation initiation factor 2 subunit 3 protein (173-472AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

Background

As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (By similarity). Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity).

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

EIF2S3

Research Areas

Epigenetics and Nuclear Signaling