EFNB1 Antibody

Size

100ul

Clone Number

Aliases

CFND antibody; CFNS antibody; Craniofrontonasal syndrome (craniofrontonasal dysplasia) antibody; EFL 3 antibody; EFL-3 antibody; EFL3 antibody; EFNB1 antibody; EFNB1_HUMAN antibody; Elk L antibody; ELK ligand antibody; ELK-L antibody; Eph related receptor tyrosine kinase ligand 2 antibody; EPH-related receptor tyrosine kinase ligand 2 antibody; Ephrin-B1 antibody; EPLG2 antibody; LERK 2 antibody; LERK-2 antibody; LERK2 antibody; Ligand of eph related kinase 2 antibody; MGC8782 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P98172

Immunogen

Recombinant Human Ephrin-B1 protein (28-237AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Binds to the receptor tyrosine kinases EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons. Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to the receptor tyrosine kinases EPHB3 (preferred), EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

EFNB1

Research Areas

Neuroscience; Developmental biology; Signal transduction