EDEM1 Antibody

Size

100ul

Clone Number

Aliases

EDEM1 antibody; EDEM antibody; KIAA0212ER degradation-enhancing alpha-mannosidase-like protein 1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q92611

Immunogen

Recombinant Human ER degradation-enhancing alpha-mannosidase-like protein 1 protein (46-128AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:200-1:500

Background

Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

EDEM1

Research Areas

Signal transduction