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ELK Biotechnology
SKU:EA366
Calreticulin Rabbit pAb
Calreticulin Rabbit pAb
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$250.00 USD
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Applications: WB
Reactivity: Human, Mouse, Rat
Source: Rabbit
Dilution: WB 1:500-1,000
Immunogen: Recombinant Protein
Storage_stability: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Clonality: Polyclonal
Isotype: IgG
Concentration: 1mg/mL
Observed_band(KD): 55kDa
Human_gene_id: 811
Human_swiss_prot_no: P27797
Subcellular_location: Cytoplasm, Endoplasmic reticulum, Extracellular matrix, Sarcoplasmic reticulum, Secreted
Other_name: CALR, Calregulin, cC1qR, CRP55, CRT, CRTC, ERp60, grp60, HACBP, RO, SSA
Background: Calcium is a universal signaling molecule involved in many cellular functions such as cell motility, metabolism, protein modification, protein folding, and apoptosis. Calcium is stored in the endoplasmic reticulum (ER), where it is buffered by calcium binding chaperones such as calnexin and calreticulin, and is released via the IP3 Receptor channel . Calreticulin also functions as an ER chaperone that ensures proper folding and quality control of newly synthesized glycoproteins. As such, calreticulin presumably does not alter protein folding but regulates proper timing for efficient folding and subunit assembly. Furthermore, calreticulin retains proteins in non-native conformation within the ER and targets them for degradation .
Reactivity: Human, Mouse, Rat
Source: Rabbit
Dilution: WB 1:500-1,000
Immunogen: Recombinant Protein
Storage_stability: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Clonality: Polyclonal
Isotype: IgG
Concentration: 1mg/mL
Observed_band(KD): 55kDa
Human_gene_id: 811
Human_swiss_prot_no: P27797
Subcellular_location: Cytoplasm, Endoplasmic reticulum, Extracellular matrix, Sarcoplasmic reticulum, Secreted
Other_name: CALR, Calregulin, cC1qR, CRP55, CRT, CRTC, ERp60, grp60, HACBP, RO, SSA
Background: Calcium is a universal signaling molecule involved in many cellular functions such as cell motility, metabolism, protein modification, protein folding, and apoptosis. Calcium is stored in the endoplasmic reticulum (ER), where it is buffered by calcium binding chaperones such as calnexin and calreticulin, and is released via the IP3 Receptor channel . Calreticulin also functions as an ER chaperone that ensures proper folding and quality control of newly synthesized glycoproteins. As such, calreticulin presumably does not alter protein folding but regulates proper timing for efficient folding and subunit assembly. Furthermore, calreticulin retains proteins in non-native conformation within the ER and targets them for degradation .
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