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ELK Biotechnology
SKU:EA321
CD10 Rabbit pAb
CD10 Rabbit pAb
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$250.00 USD
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Applications: IHC
Reactivity: Human, Rat, Mouse
Source: Rabbit
Dilution: IHC 1:200-500
Immunogen: Recombinant Protein
Storage_stability: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Clonality: Polyclonal
Isotype: IgG
Concentration: 1mg/mL
Observed_band(KD): 85kDa
Human_gene_id: 4311
Human_swiss_prot_no: P08473
Subcellular_location: Cell membrane
Other_name: CALLA, Enkephalinase,MME,NEP, Neutral endopeptidase antibody
Background: CD10 is a zinc-dependent metalloprotease enzyme that degrades a number of small secreted peptides, most notably the amyloid beta peptide whose abnormal misfolding and aggregation in neural tissue has been implicated as a cause of Alzheimer's disease. Synthesized as a membrane-bound protein, the neprilysin ectodomain is released into the extracellular domain after it has been transported from the Golgi apparatus to the cell surface. In neurons, neprilysin is regulated by the protein nicastrin, a component of the gamma secretase complex that performs a necessary step in processing amyloid precursor protein to amyloid beta.
Reactivity: Human, Rat, Mouse
Source: Rabbit
Dilution: IHC 1:200-500
Immunogen: Recombinant Protein
Storage_stability: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Clonality: Polyclonal
Isotype: IgG
Concentration: 1mg/mL
Observed_band(KD): 85kDa
Human_gene_id: 4311
Human_swiss_prot_no: P08473
Subcellular_location: Cell membrane
Other_name: CALLA, Enkephalinase,MME,NEP, Neutral endopeptidase antibody
Background: CD10 is a zinc-dependent metalloprotease enzyme that degrades a number of small secreted peptides, most notably the amyloid beta peptide whose abnormal misfolding and aggregation in neural tissue has been implicated as a cause of Alzheimer's disease. Synthesized as a membrane-bound protein, the neprilysin ectodomain is released into the extracellular domain after it has been transported from the Golgi apparatus to the cell surface. In neurons, neprilysin is regulated by the protein nicastrin, a component of the gamma secretase complex that performs a necessary step in processing amyloid precursor protein to amyloid beta.
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