DROSHA Antibody

Size

100ul

Clone Number

Aliases

DROSHA antibody; Drosha double stranded RNA specific endoribonuclease antibody; Drosha ribonuclease type III antibody; Etohi2 antibody; HSA242976 antibody; Nuclear RNase III Drosha antibody; p241 antibody; Protein Drosha antibody; Putative protein p241 which interacts with transcription factor Sp1 antibody; Putative ribonuclease III antibody; RANSE3L antibody; Ribonuclease 3 antibody; Ribonuclease III antibody; Ribonuclease III nuclear antibody; Ribonuclease type III nuclear antibody; RibonucleaseIII antibody; RN 3 antibody; RN3 antibody; RNase 3 antibody; RNase III antibody; RNase3 antibody; RNASE3L antibody; RNaseIII antibody; RNASEN antibody; RNC_HUMAN antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9NRR4

Immunogen

Recombinant Human Ribonuclease 3 protein (1-100AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:200-1:500

Background

Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3\' and 5\' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Antigen Affinity purified & Affinity purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

DROSHA

Research Areas

Signal Transduction