DR6(Phospho-Ser562) Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1)| and induces cell apoptosis. Through its death domain| the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein| which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation| and may be involved in inflammation and immune regulation.

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized phosho peptide around human DR6 (Ser562)

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

synonyms

DR6 ;Ser562; Tumor necrosis factor receptor superfamily member 21; Death receptor 6; CD antigen CD358