DPP4 Antibody

Size

100ug

Clone Number

Aliases

ADABP antibody; ADCP-2 antibody; ADCP2 antibody; Adenosine deaminase complexing protein 2 antibody; CD26 antibody; Dipeptidyl peptidase 4 antibody; Dipeptidyl peptidase 4 soluble form antibody; Dipeptidyl peptidase IV antibody; Dipeptidyl peptidase IV membrane form antibody; Dipeptidyl peptidase IV soluble form antibody; DPP IV antibody; DPP4 antibody; DPP4_HUMAN antibody; DPPIV antibody; T-cell activation antigen CD26 antibody; TP103 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P27487

Immunogen

Recombinant Human Dipeptidyl peptidase 4 protein (473-588AA)

Raised in

Rabbit

Species Reactivity

Human, Rat

Tested Applications

ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200

Background

Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

DPP4

Research Areas

Cancer; Cell biology; Immunology; Metabolism; Stem cells