Dok-7 Polyclonal Antibody

Ab type

Primary antibody

Background

The docking protein 7 encoded by DOK7 is essential for neuromuscular synaptogenesis. The protein functions in aneural activation of muscle-specific receptor kinase, which is required for postsynaptic differentiation, and in the subsequent clustering of the acetylcholine receptor in myotubes. This protein can also induce autophosphorylation of muscle-specific receptor kinase. Mutations in DOK7 are a cause of familial limb-girdle myasthenia autosomal recessive, which is also known as congenital myasthenic syndrome type 1B. Alternative splicing results in multiple transcript variants.

Reactivity

Human;Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human DOK7. AA range:10-59

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

53097

synonyms

DOK7; C4orf25; Protein Dok-7; Downstream of tyrosine kinase 7