DOCK7 Antibody, Biotin conjugated

Size

100ug

Clone Number

Aliases

DOCK7 antibody; KIAA1771Dedicator of cytokinesis protein 7 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q96N67

Immunogen

Recombinant Human Dedicator of cytokinesis protein 7 protein (1440-1671AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 \\\'Ser-15\\\' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Biotin

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

DOCK7

Research Areas

Neuroscience; Developmental biology; Signal transduction