DNAJC2 Antibody

Size

100ul

Clone Number

Aliases

AU020218 antibody; DnaJ (Hsp40) homolog subfamily C member 2 antibody; DnaJ homolog subfamily C member 2 antibody; Dnajc2 antibody; DNJC2_HUMAN antibody; M phase phosphoprotein 11 antibody; M-phase phosphoprotein 11 antibody; MGC105894 antibody; MIDA1 antibody; MPHOSPH11 antibody; MPP11 antibody; OTTMUSP00000031226 antibody; ZRF1 antibody; Zrf2 antibody; ZUO1 antibody; Zuotin related factor 1 antibody; Zuotin related factor 2 antibody; Zuotin-related factor 1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q99543

Immunogen

Recombinant Human DnaJ homolog subfamily C member 2 protein (1-140AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at \\\'Lys-119\\\' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5\\\'-GTCAAGC-3\\\'.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

DNAJC2

Research Areas

Others