DNAJC10 Antibody

Size

100ul

Clone Number

Aliases

DNAJC10 antibody; ERDJ5 antibody; UNQ495/PRO1012DnaJ homolog subfamily C member 10 antibody; EC 1.8.4.- antibody; Endoplasmic reticulum DNA J domain-containing protein 5 antibody; ER-resident protein ERdj5 antibody; ERdj5 antibody; Macrothioredoxin antibody; MTHr antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q8IXB1

Immunogen

Recombinant Human DnaJ homolog subfamily C member 10 protein (521-793AA)

Raised in

Rabbit

Species Reactivity

Human, Rat

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200

Background

Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

DNAJC10

Research Areas

Signal transduction