DNAJB6 Antibody

Size

100ug

Clone Number

Aliases

DJ4 antibody; DnaJ antibody; DnaJ (Hsp40) homolog subfamily B member 6 antibody; DNAJ B6 antibody; DnaJ homolog subfamily B member 6 antibody; DnaJ like 2 protein antibody; DNAJB6 antibody; DNJB6_HUMAN antibody; Heat shock protein J2 antibody; HHDJ1 antibody; HSJ-2 antibody; HSJ2 antibody; LGMD1E antibody; MRJ antibody; MSJ-1 antibody; MSJ1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O75190

Immunogen

Recombinant Human DnaJ homolog subfamily B member 6 protein (208-326AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse

Tested Applications

ELISA, WB, IF; Recommended dilution: WB:1:2000-1:10000, IF:1:50-1:200

Background

Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

DNAJB6

Research Areas

Neuroscience; Signal transduction