DMPK Antibody

Size

100ug

Clone Number

Aliases

DM 1 antibody; DM antibody; DM kinase antibody; DM protein kinase antibody; DM-kinase antibody; DM1 antibody; DM1 protein kinase antibody; DM1PK antibody; DMK antibody; DMPK antibody; DMPK_HUMAN antibody; Dystrophia myotonica 1 antibody; Dystrophia myotonica protein kinase antibody; MDPK antibody; MT PK antibody; MT-PK antibody; Myotonic dystrophy associated protein kinase antibody; Myotonic dystrophy protein kinase antibody; Myotonin protein kinase A antibody; Myotonin protein kinase antibody; Myotonin-protein kinase antibody; Thymopoietin homolog antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q09013

Immunogen

Recombinant Human Myotonin-protein kinase protein (243-424AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:500-1:1000, IF:1:50-1:200

Background

Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

DMPK

Research Areas

Neuroscience; Signal transduction